Statin islands and PPAR ligands in platelets.

نویسندگان

  • Richard P Phipps
  • Neil Blumberg
چکیده

Platelets are formed from megakaryocytes, where they are released into the blood stream via proplatelet extensions into the blood vessel lumen.1 Being the most numerous “white blood cell” and despite lacking a nucleus, they are highly complex cells containing a surface connected canalicular and tubular system, mitochondria, granules, and bioactive mediators. Platelets are well-known for their seminal role in hemostasis and thrombosis.2 Aside from these physiological functions, new roles for platelets are being identified in unwanted thrombosis that occurs in diabetes and cancer.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Compare the Effect of Eicosapentaenoic Acid and Oxidized Low-Density Lipoprotein on the Expression of CD36 and Peroxisome Proliferator-Activated Receptor Gamma

Background: There is evidence that CD36 promotes foam cell formation through internalizing oxidized LDL (ox-LDL) into macrophages therefore, it plays a key role in pathogenesis of atherosclerosis. In addition, CD36 expression seems to be mediated by nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of the present study was to evaluate and compare the effect of ...

متن کامل

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation

BACKGROUND Peroxisome proliferator-activated receptor-(gamma) (PPAR(gamma)) is expressed in human platelets although in the absence of genomic regulation in these cells, its functions are unclear. OBJECTIVE In the present study, we aimed to demonstrate the ability of PPAR(gamma) ligands to modulate collagen-stimulated platelet function and suppress activation of the glycoprotein VI (GPVI) sig...

متن کامل

Differential effects of peroxisome proliferator-activated receptor ligands and sulfonylurea plus statin treatment on plasma concentrations of adipokines in type 2 diabetes with dyslipidemia.

OBJECTIVES Peroxisome proliferator-activated receptor gamma is the master regulator of adipocyte differentiation and controls many adipocyte genes in response to anti-diabetic thiazolidinediones (TZDs) and lipid-lowering fibrates. We hypothesized that the combination of TZD+fibrate may be better than the sulfonylurea + statin approach regarding modifying the adipokine profile in diabetic patien...

متن کامل

Peroxisome proliferator-activated receptors mediate pleiotropic actions of statins.

High plasma concentrations of LDL-cholesterol (LDL-c) are a major risk factor for atherosclerosis, a chronic inflammatory disease of the large arteries. Statins are potent inhibitors of cholesterol biosynthesis which efficiently decrease plasma LDL-c concentrations. A large number of clinical trials has shown beneficial effects of statins in the primary and secondary prevention of cardiovascula...

متن کامل

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Human bone marrow megakaryocytes and platelets express PPAR , and PPAR agonists blunt platelet release of CD40 ligand and thromboxanes

Peroxisome proliferator-activated receptor (PPAR ) is a ligand-activated transcription factor important in lipid metabolism, diabetes, and inflammation. We evaluated whether human platelets and megakaryocytes express PPAR and whether PPAR agonists influence platelet release of bioactive mediators. Although PPAR is mainly considered a nuclear receptor, we show that enucleate platelets highly exp...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Arteriosclerosis, thrombosis, and vascular biology

دوره 29 5  شماره 

صفحات  -

تاریخ انتشار 2009